GLP r3
$100.00
10 mg / vial
Third-Party Tested | U.S.–Made | Research-Grade
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Description
Description
GLP r3 • 10 mg / vial
Tier One Biosystems – Third-Party Tested | U.S.–Made | Research-Grade
Biological Activity
GLP r3 is Tier One’s research name for reta (LY3437943), a single-peptide tri-agonist that activates GLP-1R, GIPR, and GCGR. It was engineered for balanced multi-receptor signaling and extended exposure through lipidation chemistry. Investigational studies and clinical reports characterize robust metabolic pathway engagement consistent with the tri-agonist design.
In Vitro / In Vivo Data
- Receptor activity (representative EC50): GLP-1R ~0.064 nM, GIPR ~0.78 nM, GCGR ~5.8 nM (assay/vendor data).
- Peptide length: ~39 aa; lipidated Lys side chain (C20 diacid–γGlu–AEEA linker) to prolong exposure.
- Exposure: Long-acting tri-agonist profile reported in preclinical/clinical literature. (Follow your lab SOPs; conditions vary by model.) (Cell)
Purity & Documentation
- Purity (HPLC): ≥99%
- Independently verified for identity, potency, and sterility
Molecular Details
| Property | Value |
|---|---|
| Chemical Formula (free peptide) | C₂₂₁H₃₄₂N₄₆O₆₈ |
| Average Molecular Weight | ~4731.33 g/mol |
| Exact/Monoisotopic Mass | ~4728.47 Da |
| CAS No. | 2381089-83-2 |
| Representative Sequence | Tyr–Aib–Gln–Gly–Thr–Phe–Thr–Ser–Asp–Tyr–Ser–Ile–αMeLeu–Leu–Asp–Lys–[diacid-C20–γGlu–AEEA–Lys]–Ala–Gln–Aib–Ala–Phe–Ile–Glu–Tyr–Leu–Leu–Glu–Gly–Gly–Pro–Ser–Ser–Gly–Ala–Pro–Pro–Pro–Ser–NH₂ (39 aa). |
Physical Properties
| Property | Specification |
|---|---|
| Appearance | White to off-white lyophilized powder |
| Solubility (25 °C, in vitro) | H₂O: ~33 mg/mL · DMSO: ~50 mg/mL |
| Storage (sealed) | −20 °C (long-term), protected from light & moisture; avoid repeat freeze–thaw |
Shipping & Handling
Ships at ambient temperature within the U.S. unless otherwise requested. Maintain cold-chain conditions for extended storage upon receipt.
References
- PubChem: Retatrutide record (formula & MW). (PubChem)
- KEGG DRUG D12430: Formula, exact mass, sequence motif. (kegg.jp)
- MedChemExpress / NovoPro: Sequence with Aib/αMeLeu and C20-linker; EC50 data; general specs. (MedChemExpress)
- Coskun et al., Cell Metab (2022): LY3437943 design & 39-aa tri-agonist engineering. (Cell)
- Jastreboff et al., NEJM (2023): Clinical characterization of tri-agonism. (New England Journal of Medicine)
- FDA GINAS: Substance identifiers for retatrutide (LY-3437943). (precision.fda.gov)
Research Use Only – Not for Human Consumption
Supplied exclusively for laboratory research, analytical testing, and scientific investigation.
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