Methylene Blue
10 mg / cap
60 caps / bottle
Third-Party Tested | U.S.–Made | Research-Grade
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Description
Description
Methylene Blue • 10 mg / capsule • 60 capsules / bottle
Tier One Biosystems – Third-Party Tested | U.S.–Made | Research-Grade
Biological Activity
Methylene Blue (MB) is a synthetic phenothiazine compound with redox-active properties, long studied as a mitochondrial electron carrier, monoamine oxidase (MAO) inhibitor, and cellular protectant.
In vitro and in vivo work suggests Methylene Blue can enhance mitochondrial respiration by facilitating electron transfer between Complex I–III and cytochrome c, improve ATP synthesis under stress, and reduce reactive oxygen species (ROS) formation.
It has also been explored as a research tool in studies of neuroprotection, photodynamic therapy, and metabolic resilience.
In Vivo / In Vitro Data
Experimental models have examined Methylene Blue for:
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Mitochondrial support and ATP restoration after oxidative stress.
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Cognitive and neuroprotective effects in rodent memory and ischemia studies.
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Photosensitizing and antimicrobial properties under specific light wavelengths.
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MAO-A inhibition and potential serotonergic interactions in neural tissue.
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Reduction of methemoglobin to hemoglobin in hematologic models.
Experimental parameters vary by model and application; consult primary literature for dose ranges and vehicle data.
(Representative sources: J Neurosci 2016 | Free Rad Biol Med 2020 | Front Pharmacol 2022)
Purity & Documentation
Purity (HPLC): ≥ 99 %
Independently verified for identity, potency, and microbial cleanliness
Molecular Details
| Property | Value |
|---|---|
| Compound Class | Phenothiazine redox compound |
| Chemical Name | 3,7-bis(Dimethylamino)phenothiazin-5-ium chloride |
| Chemical Formula | C₁₆H₁₈ClN₃S |
| Average Molecular Weight | 319.85 g/mol |
| CAS No. | 61-73-4 |
| EC Number | 200-515-2 |
| IUPAC Name | 3,7-bis(Dimethylamino)phenothiazin-5-ium chloride |
Physical Properties
| Property | Specification |
|---|---|
| Appearance | Dark blue powder encapsulated in opaque gelatin capsules |
| Solubility (in vitro) | Water soluble; forms deep blue solution |
| Storage (sealed) | Room temp (< 25 °C) dry and dark; refrigerate for long-term stability |
| Handling | Avoid contact with skin or light exposure; wear lab PPE when handling powder or solutions |
References
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Rojas JC et al., J Neurosci (2016) – Low-dose Methylene Blue enhances mitochondrial respiration and memory. [PubMed]
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Atamna H et al., Free Rad Biol Med (2020) – MB as an alternative electron carrier in mitochondrial function. [PubMed]
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Khalil S et al., Front Pharmacol (2022) – Redox cycling and neuroprotective mechanisms of Methylene Blue. [PubMed]
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PubChem – Compound summary for Methylene Blue chloride (61-73-4). [PubChem]
Research Use Only – Not for Human Consumption
Supplied exclusively for laboratory research, analytical testing, and scientific investigation.
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