BPC-157
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Research Peptide – Third-Party Tested | U.S.-Made
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Description
Description
BPC-157 • 5 mg / vial
Tier One Biosystems – Third-Party Tested | U.S.-Made | Research-Grade
Overview
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide (15 amino acids) originally isolated as a fragment of gastric juice proteins. Preclinical research suggests it may support connective-tissue, muscle, nerve, and gastrointestinal repair by influencing growth-factor signaling, angiogenesis, and cytokine modulation.
Research use only. Not for human consumption.
Research Highlights
Wound & Tissue Healing
Animal studies show BPC-157 may stimulate VEGF-driven angiogenesis, fibroblast migration, and collagen synthesis, supporting faster closure and stronger remodeling of skin, tendon, muscle, and bone injuries .
Tendon & Ligament Support
In murine tendon-cell models, BPC-157 enhanced focal adhesion kinase (FAK) / paxillin signaling and F-actin formation, increasing fibroblast survival and migration even under oxidative stress .
Gastrointestinal Integrity
BPC-157 displayed gastroprotective and anti-ulcer activity, outperforming EGF, FGF, and VEGF across esophageal, gastric, and intestinal lesion models .
It may also counteract excess serotonin signaling (5-HT2A) in the gut, contributing to balanced motility and blood flow .
Systemic & Neurological Findings
– Reduced damage in experimental traumatic brain injury models and lowered mortality .
– Modulated dopaminergic pathways, reversing amphetamine-induced hypersensitivity and haloperidol-related effects .
– Supported muscle repair in the presence of corticosteroids .
Purity & Documentation
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Purity (HPLC): ≥99 %
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Independently verified for identity, potency, and sterility
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Certificate of Analysis (COA), SDS, and full HPLC / LC-MS data provided with every batch
Molecular Details
| Property | Value |
|---|---|
| Molecular Weight | 1419.54 g/mol |
| Formula | C₆₂H₉₈N₁₆O₂₂ |
| CAS No. | 137525-51-0 |
| Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val |
| Sequence Shortening | GEPPPGKPADDAGLV |
Physical Properties
| Property | Specification |
|---|---|
| Appearance | Solid, white to off-white lyophilized powder |
| Storage (sealed) | −20 °C = 1 year · −80 °C = 2 years |
| Solubility (in vitro) | H₂O: ≥100 mg/mL (70.45 mM) · DMSO: ≥50 mg/mL (35.22 mM) with ultrasonic assistance |
Key Pre-Clinical Citations
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Chang C-H et al. J Appl Physiol. 2011. PubMed
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Ormsbee HS 3rd, Fondacaro JD. Proc Soc Exp Biol Med. 1985. PubMed
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Sikiric P et al. Curr Neuropharmacol. 2016. Full text
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Krivic A et al. Inflamm Res. 2008. DOI
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Seiwerth S et al. J Physiol Paris. 1997. PubMed
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Huang T et al. Drug Des Devel Ther. 2015. DOI
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Seiwerth S et al. Curr Pharm Des. 2018. PubMed
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Sikiric P. Inflammopharmacology. 1999. PubMed
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Pevec D et al. Med Sci Monit. 2010. PubMed
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Jelovac N et al. Biol Psychiatry. 1998. PubMed
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Tudor M et al. Regul Pept. 2010. DOI
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Gwyer D et al. Cell Tissue Res. 2019. DOI
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Veljaca M et al. Adv GI Pharmacol. 2002. Bib.irb
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Phase I Clinical Trial – Safety & Pharmacokinetics. ClinicalTrials.gov NCT02637284
Research Use Only – Not for Human Consumption
Tier One Biosystems provides this compound solely for laboratory research, analytical testing, and scientific investigation.
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